{"id":609,"date":"2023-05-11T10:59:48","date_gmt":"2023-05-11T08:59:48","guid":{"rendered":"https:\/\/ugabiopharma.de\/?page_id=609"},"modified":"2026-02-15T14:54:21","modified_gmt":"2026-02-15T13:54:21","slug":"cell-line-development-cld","status":"publish","type":"page","link":"https:\/\/ugabiopharma.com\/de\/cell-line-development-cld\/","title":{"rendered":"Cell Line Development (CLD)"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container video-background has-pattern-background has-mask-background full-width-video-centered gradient-container-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-background-image:radial-gradient(circle at left bottom, rgba(0,127,146,0.7) 0%,rgba(79,186,173,0) 56%);--awb-flex-wrap:wrap;\" ><div class=\"fullwidth-video\"><video preload=\"auto\" autoplay playsinline loop muted><source src=\"https:\/\/ugabiopharma.com\/wp-content\/uploads\/2024\/12\/241217_Websitebanner_CLD_10s_3Mbs_24fps.mp4\" type=\"video\/mp4\"><\/video><\/div><div class=\"fullwidth-overlay\" style=\"background-image: radial-gradient(circle at left bottom, rgba(0,127,146,0.7) 0%,rgba(79,186,173,0) 56%);\"><\/div><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1185.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:80%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.4%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:2.4%;--awb-width-medium:80%;--awb-order-medium:0;--awb-spacing-right-medium:2.4%;--awb-spacing-left-medium:2.4%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:320px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1 weiss schlagschatten keinetrennung\"><h1 style=\"text-align: left;\">Cell Line Development<\/h1>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:67px;width:100%;\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container has-pattern-background has-mask-background gradient-container-2 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1185.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:120px;width:100%;\"><\/div><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-text-color:var(--awb-color4);--awb-margin-bottom:0px;\"><h2 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:45.52;line-height:1.12;\">Mit System zur stabilen Hochleistungszelllinie<\/h2><\/div><div class=\"fusion-separator trennerheadline\" style=\"align-self: flex-start;margin-right:auto;margin-top:15px;margin-bottom:88px;width:100%;max-width:68px;\"><\/div><div class=\"fusion-text fusion-text-2\"><p>Stabile Zelllinien sind die Basis f\u00fcr die erfolgreiche Produktion von Biopharmazeutika. Unsere Prozesse im Cell Line Development (CLD) erm\u00f6glichen die individuelle Anpassung an konkrete Fragestellungen und Herausforderungen \u2013 dank modernster Technologien und analytischer Methoden. In vier Schritten werden so die Grundlagen geschaffen, um von der DNA des Zielgens zu hochproduktiven monoklonalen Zelllinien zu gelangen. Der Erfolg unseres CLD-Prozesses beruht auf speziell adaptierten CHO-Hostzelllinien und optimierten Expressionsvektoren sowie unserem leistungsstarken CHO Prime<sup>\u00ae<\/sup> Zellkulturmedium und den CHO Prime<sup>\u00ae<\/sup> Feeds.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container has-pattern-background has-mask-background gradient-container-3 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1185.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:60px;width:100%;\"><\/div><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-three\" style=\"--awb-text-color:var(--awb-color4);--awb-margin-bottom:0px;\"><h3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:31.25;line-height:1.12;\"><h3>Der CLD-Prozess bei UGA Biopharma auf einen Blick:<\/h3><\/h3><\/div><div class=\"fusion-lottie fusion-lottie-1\" data-id=\"1\"><div class=\"fusion-lottie-animation\" data-path=\"https:\/\/ugabiopharma.com\/wp-content\/uploads\/2023\/11\/uga-biopharma-cell-line-development-process.json\" data-loop=\"0\" data-reverse=\"0\" data-speed=\"1\" data-trigger=\"viewport\" data-start_point=\"0\" data-end_point=\"100\" data-animationoffset=\"top-mid-of-view\"><lottie-player speed=\"1\"><\/lottie-player><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:60px;width:100%;\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container has-pattern-background has-mask-background gradient-container-4 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1185.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:60px;width:100%;\"><\/div><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-text fusion-title-size-three\" style=\"--awb-text-color:var(--awb-color4);--awb-margin-bottom:0px;\"><h3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:31.25;line-height:1.12;\"><h3>Unsere Leistungen im Cell Line Development:<\/h3><\/h3><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-3\"><ul>\n<li>Gensynthese und Klonierung in hauseigene Expressionsvektoren f\u00fcr eine hohe Ausbeute<\/li>\n<li>Transfektion der Hostzelllinien (z. B. CHO\u2011DG44,\u00a0 CHO\u2011K1, CHO\u2011DXB11)<\/li>\n<li>Pool- oder Minipool-Generierung, Screening im Hochdurchsatz<\/li>\n<li>Single cell cloning<\/li>\n<li>Auswahl hochproduktiver Klone<\/li>\n<li>Expressionsstabilit\u00e4tsstudien<\/li>\n<li>Generierung von Zellb\u00e4nken<\/li>\n<li>Nachweis der biologischen Sicherheit<\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container has-pattern-background has-mask-background gradient-container-5 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1185.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:60px;width:100%;\"><\/div><div class=\"fusion-title title fusion-title-4 fusion-sep-none fusion-title-text fusion-title-size-three keinetrennung\" style=\"--awb-text-color:var(--awb-color4);--awb-margin-bottom:0px;\"><h3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:31.25;line-height:1.12;\"><h3>Detaillierte Dokumentation entsprechend der regulatorischen Anforderungen<\/h3><\/h3><\/div><div class=\"fusion-text fusion-text-4\"><p>Unser Cell Line Development-Team entwickelt hoch produktive Zellen mit nachgewiesener Leistung und Qualit\u00e4t: Die Stabilit\u00e4t und die Sicherheit unserer Zelllinien entsprechen den h\u00f6chsten Standards zur Erf\u00fcllung regulatorischer Vorgaben. Wir arbeiten nach EMA\/410\/01, um das TSE\/BSE-Risiko zu minimieren. Selbstverst\u00e4ndlich erhalten Sie f\u00fcr Ihre Dokumentation alle n\u00f6tigen Unterlagen:<\/p>\n<\/div><div class=\"fusion-text fusion-text-5\"><ul>\n<li>Berichte zu Vektorkonstruktion, Poolgenerierung, Klongenerierung, Stabilit\u00e4t<\/li>\n<li>Daten zur biologischen Sicherheit<\/li>\n<li>Bildbasierter Monoklonalit\u00e4tsnachweis<\/li>\n<li>Dokumentation zur Gew\u00e4hrleistung der R\u00fcckverfolgbarkeit<\/li>\n<li>Zertifikate der verwendeten Kontaktmaterialien und -reagenzien<\/li>\n<\/ul>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-6\"><p>Sie haben Fragen zum Cell Line Development? Wir freuen uns auf Ihre Nachricht!<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-609","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cell Line Development (CLD) - UGA Biopharma<\/title>\n<meta name=\"description\" content=\"Unsere Prozesse im Cell Line Development erm\u00f6glichen die individuelle Anpassung an konkrete Fragestellungen und Herausforderungen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ugabiopharma.com\/de\/cell-line-development-cld\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell Line Development (CLD) - 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